The Light RailLink station at Camden Yards will be closed for construction.
Riders are encouraged to use the station near the Baltimore Convention Center instead.
The new station design will include a larger waiting area, restrooms new ticket machines and an MTA police substation.
While the Camden Station is closed, the Penn-Camden shuttle will run only between Penn Station and Mt. Royal Station. The MARC Train service to the Camden Station will be unaffected.
Construction is expected to be finished by the end of March 2019.
The Orioles' home opener against the New York Yankees is set for April 4.