Police responded to the 1500 block of Holbrook Street around 4:49 p.m. for what initially came out as a traffic accident.
When units arrived to the scene, they found a man in a vehicle suffering from gunshot wounds to the body.
The victim was transported to a hospital for treatment. Police believe the man is in his twenties.
Shortly after arrival, medical personnel at Johns Hopkins pronounced the victim dead.
Anyone with information is urged to contact the Baltimore Police Department's Homicide Section at 410-396-2100.