Reynolds ran for 144 yards on 24 carries, completed 9 of 17 passes for 126 yards and had a reception for 47 yards on a trick play.
The 5-foot-11 senior leaves Navy (11-2) as the NCAA career leader with 88 touchdowns and 530 points. His 4,559 yards rushing are the most by a quarterback in NCAA history.
Qadree Ollison rushed for 73 yards and scored two touchdowns for Pitt. Nate Peterman threw a TD pass but was intercepted three times.
It all added up to a disappointing ending for the Panthers (8-5) in their first season under coach Pat Narduzzi.