The Orioles are up 2-0 in their four-game series against the Nationals after a win at home Tuesday night, giving the Orioles the best record in baseball.
The O's won 5-4 after going into extra innings.
Mark Trumbo hit the game-winning walk-off single in the 12th inning.
The Battle of the Beltway moves back to Washington D.C. Wednesday night for the last two games in the series.
Wade Miley will be on the mound Wednesday. The game starts at 7:05 p.m.