The Orioles completed a three-game sweep of the Indians with a 5-3 win.
The O's won the game in the bottom of the ninth when pinch-hitter Nolan Reimold hit a two-out homer off closer Cody Allen. The Orioles, who lead the American League East, took the season series from Cleveland, who leads the AL Central, 5-1.
Baltimore maintained its game and a-half lead over Boston in the closest division race in baseball.
The O's are the best home team in baseball with a record of 36-14.