The Orioles' 8-3 loss to the Yankees Tuesday gives Baltimore its eight loss in nine games.
Brett Gardner and Matt Holliday each homered twice, Aaron Judge drove in two runs and the Yankees received a solid pitching performance from Luis Severino.
Gardner set the tone for the AL East leaders by connecting on the third pitch from Chris Tillman (1-2), who had not allowed a home run in his previous four starts this season.
Holliday went deep in the first inning and again in the third for his 22nd career multihomer game. Gardner's second solo shot sparked a three-run fourth that made it 8-0.
Severino (4-2) gave up one run and seven hits over 6 1/3 innings.
Trey Mancini had three hits and an RBI for the Orioles, who have lost eight of nine and 14 of 18.
The Orioles face the Yankees at 7:05 p.m. Wednesday for the final game in their series. Kevin Gausman will be on the mound for Baltimore.