Fluoroquinolones are commonly prescribed as Cipro and Levaquin.
Last year, an FDA database revealed 3,000 deaths had been linked to the drug and another 2,000 people complained of side effects including kidney infections and nerve damage.
Now, the FDA is advising their use be restricted for certain uncomplicated infections and is warning about severe side effects.
In an advisory Thursday, the FDA said the side effects generally outweigh the benefits for patients with things like sinusitis and bronchitis. Doctors are being told to "stop systemic" treatment immediately if a patient reports serious side effects.