Police were called around 7:51 p.m. to the 4500 block of Edmondson Avenue, where they found a 45-year-old man suffering from multiple stab wounds.
Medics arrived and transported the victim to University of Maryland Shock Trauma for treatment.
Unfortunately, the victim was pronounced dead shortly after arrival.
Police believe the man and woman along with a car pictured above could lead an arrest in the case.
Anyone with information is asked to call Metro Crime Stoppers tip line, at 1-866-7LOCKUP or text tips and video to 443-902-4824.