Police responded to the 300 block of South Dallas Street in southeast Baltimore for a stabbing report Tuesday.
When officers arrived, they found a 48-year-old man stabbed in the chest. The man later died at the hospital.
Officers believe the stabbing was sparked by a verbal altercation with an unidentified man.
This is Baltimore's 328th murder this year.
Anyone with information is asked to contact Homicide Detectives at 410-396-2100 or Metro Crime Stoppers at 1-866-7LOCKUP.